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- $Unique_ID{BRK00412}
- $Pretitle{}
- $Title{Tiredness and Dangerous Disease}
- $Subject{myasthenia autoimmune weakness Nervous System fatigue droopy eyelids
- ptosis gravis women muscles breathing affected autoimmune attack receptor
- acetylcholine nerve nerves eyes double vision cholinesterase inhibitors
- muscle}
- $Volume{F-2,U-2}
- $Log{}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
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-
- Tiredness and Dangerous Disease
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-
- QUESTION: I have never been athletic, but of late, even the slightest
- exercise leaves me weary and tired. Lately my boss has commented how droopy
- and tired looking I look, for there are times I can scarcely open my eyes. My
- girl friend thinks I am suffering from a weird, but dangerous disease. I
- don't want to go to my doctor with a silly complaint like just being tired.
- What do you think?
-
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-
- ANSWER: Though the complaint of fatigue is a frequent one in daily practice
- with so many possible causes and explanations, there are a few clues in your
- letter that make me side with your girl friend. Fatigue that follows brief
- exercise and droopy eyelids (called ptosis) are the signs of a disorder known
- as myasthenia gravis, a rare disease that is first seen in women between the
- ages of 20 to 40 years of age. The symptoms may come and go over a brief
- period, and are sometimes hard to nail down, but can become progressive and
- life threatening when the muscles that are responsible for breathing become
- affected. It is believed that the condition is the result of an autoimmune
- attack on the receptor in the connection between nerves and muscles that
- responds to the chemical acetylcholine, and permits the transmission of the
- stimulus that makes the muscles contract. When this mechanism fails, muscles
- do not contract and the patient experiences the weakness. When it affects the
- muscles that control the eyes, double vision may result. The physician may
- test for this disease by injecting a substance, edrophonium, into a vein. A
- sufferer of myasthenia will experience a sudden, though short lasting,
- improvement in muscle function. Other tests may be used to confirm the
- diagnoses, and the good news is that a class of medication called
- cholinesterase inhibitors are useful oral medications that can successfully
- treat the disease. The medications must be carefully dosed and controlled,
- and require ongoing evaluation and modification. Take the advice of both your
- girl friend and me, get to your physician now, and take this along as an
- expression of my opinion.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
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-